My HormonologyBothered by a heavy menstrual flow and want to lighten it? If you can take NSAIDs (such as Advil, Motrin IB or Aleve), try popping one to three spaced apart on the three days leading up to your period. (You can guesstimate when your period is due, but never exceed the recommended dosage on the label.) Research shows this can reduce flow by 25% to 35% by lowering the production of prostaglandins, hormone-like chemicals that play a key role in the shedding of the uterine lining. If your period is so heavy that NSAIDs aren’t effective or you can’t take NSAIDs, visit your doctor. There are prescription medications and hormonal IUDs available that can lighten a severe menstrual flow.