My HormonologyBefore your premenstrual Week 4 rolls around, schedule special activities you love, but don’t do often—such as a mani/pedi, a trip to the doughnut shop or simply vegging on the couch and catching up with all your DVR’d TV shows. Research shows that once-in-awhile treats boost the same feel-good brain chemicals that plunge in Week 4 due to descending estrogen. Result: A temporary lift in mood that chases off premenstrual blues and irritation!